Scotland have confirmed a trio of squad withdrawals following their Autumn Nations Series loss against South Africa on Sunday.
Gregor Townsend's side fell to a 32-15 defeat at Scottish Gas Murrayfield, with the Scotland head coach claiming it was one of the best performances of his tenure.
Max Williamson and Jack Dempsey featured in the match, but will both now miss the remaining November fixtures, against Portgual this weekend and Australia next, because of injury.
Dempsey has sustained a shoulder injury, while Williamson has pulled out due to a hand injury.
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Gregor Brown, who did not feature against the Springboks but did earn his first Murrayfield cap against Fiji, is also out with a rib injury.
Replacing them are Johnny Matthews, the Glasgow Warriors hooker, and Scarlets prop Alec Hepburn.
Scotland host Portugal on Saturday before taking on Australia in their final test on November 24.
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